Therapeutic Cannabis for Multiple Sclerosis (MS)
Multiple sclerosis (MS) is a chronic condition that affects the central nervous system, disrupting communication between the brain and body. Symptoms vary widely, including muscle spasticity, chronic pain, vision loss, fatigue, difficulty sleeping, and bladder dysfunction. Cannabis has emerged as a potential option to help people manage these symptoms when other treatments fall short. Research has shown that certain cannabis products, particularly those containing THC and CBD, may reduce muscle spasticity, relieve nerve pain, and improve sleep quality. Many people living with MS have found cannabis to be beneficial for managing their symptoms and improving their quality of life.
Types of Products
Flower – Vaporizing or smoking provides immediate relief
Vapes – Immediate relief, easy to use
Concentrates – Strong, immediate relief
Edibles – Long-lasting relief, more body effects
Tinctures – Fairly quick onset with long-lasting effects, small dose titration
Topicals – Targeted relief for pain, stiffness, and spasms
Symptom Management
- The endocannabinoid system plays a role in motor control, which explains why the cannabinoids found in cannabis can help
- THC, especially in combination with CBD, may be most effective for reducing spasticity
- Cannabis cultivars containing the terpenes linalool and beta-myrcene may help reduce muscle spasticity
- Cannabis, particularly THC, can affect pain perception and reduce chronic pain
- CBD/THC products in a 1:1 ratio may be most effective for nerve pain
- Cultivars with beta-caryophyllene, beta-myrcene, and linalool may help relieve pain
- MS-related pain, spasms, or anxiety can disrupt sleep
- THC and CBN may help initiate and maintain sleep, while CBD can reduce anxiety-related insomnia in some cases
- Indica cultivars are typically preferred for help with sleep
- THC and other cannabinoids may improve mood and help with depression
- Cultivars with d-limonene may provide uplifting effects
- CBD may help reduce anxiety without any intoxicating effects
- THC and CBD combined may improve quality of life
- Some people report improved bladder control when using cannabis
- Evidence is mixed, but some trials show modest improvements in urinary frequency and urgency
If you're considering cannabis for MS, it's best to:
Consult a neurologist who is familiar with MS and cannabis
Use regulated, independently tested products
Monitor symptom response and side effects closely
Potential Side Effects
- dizziness
- dry mouth
- fatigue
- impaired cognition
- psychiatric effects (in rare cases, especially with THC)
Learn more about MS at nationalmssociety.org
Disclaimer: This is an educational document and is not intended to be taken as medical advice. Please consult your medical provider if you have questions related to your healthcare.
Updated May 29, 2025
